This sound is from Def Jam: Fight For NY Soundboard

The game was spun off into a 2006 PlayStation Portable game called Def Jam Fight for NY The Takeover. It is a sequel to Def Jam Vendetta and is followed by Def Jam Icon. The only artists from the original game that did not appear in the sequel were DMX, Keith Murray, Christina Milian and Funkmaster Flex.
See also: Def Jam Fight for NY: The Takeover, Def Jam Vendetta, Def Jam: Icon, Erick Sermon, Joe Budden, and Method Man filmography.