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Reynolds himself would eventually portray the character in the X-Men film series. The character first appeared in New Mutants #98 (cover-dated Feb. 1991) Reynolds attributes Cable & Deadpool #2 to what got him invested in the character and inspired him to bring the character to the movies.
See also: Deadpool 2, Deadpool (film), Marvel Cinematic Universe: Phase Six, X-Men (film series), Weasel (Marvel Comics), Deadpool (soundtrack).